Current Issue : July-September Volume : 2020 Issue Number : 3 Articles : 5 Articles
Among novel drug delivery system buccal mucoadhesive system offers certain unique advantages for the drugs which cannot be easily administered by oral or intravenous route due to their ability to adhere and remain on the oral mucosa to release their drug content gradually. Mucoadhesion is the process where polymers attached to biological substrate, synthetic or natural molecules, to mucus epithelial surface. Buccal mucoadhesive film improve the therapeutic effect of drugs by increasing absorption of drugs through oral mucosa and mucoadhesive polymers increases the contact time with the mucus membranes. This article extensively reviews the brief description of the anatomical structure of oral mucosa, mechanism of drug absorption, aspects of dosage form design, mucoadhesion and mucoadhesive polymers followed by permeation enhancer with its mechanism of actions....
Dithranol is a most commonly used in treatment of psoriasis due to its various effects such as keratolytic, anti-eczema, antifungal properties. It is used along with salicylic acid for prevention of its oxidation. The keratolytic property of the dithranol makes it popular in the treatment of psoriasis, but during long term use patients reported some side effects like burning sensation, inflammation, irritation and hyper-pigmentation. No other drugs are more effective as compare to dithranol. In addition, dithranol is used along with other drugs like betamethasone, hydroquinone and lignocaine to improve its effects and decrease its side effects. Our study reveals the compatibility of some drugs used in dermatological problems. These drugs uniformly mixed together in various proportions and kept the samples in different temperature conditions for 21 days. After completion of specified period the samples were evaluated physically follow by physical appearance, color, state and stability was also evaluated by thermal analysis using DSC for finding physical constant of samples. Moreover, chemical stability and compatibility were evaluated through FTIR. There were no changes observed in the results of drugs basics physical evaluation. No changed observed in their physical constant also there were no changed observed in chemical structural properties of drugs. The study concludes that the drugs used in the study were compatible with each other....
Antidepressants are a type of medicine used to treat major depressive disorder, some anxiety disorders, some chronic pain conditions, obsessive-compulsive disorder (OCD) and to help manage some addictions. Paroxetine HCl is a selective serotonin reuptake inhibitor anti-depressant with poor bioavailability and aqueous solubility. The aim of the present study was to design paroxetine HCl solid lipid nano-particles and to evaluate them. The paroxetine HCl loaded solid lipid nanoparticles were prepared by using the different lipids like tristearin and GMS with tween 80 as a surfactants in combination with soy lecithin as a stabilizer by hot melt homogenization followed by ultra-sonication method. FTIR studies confirmed that there was no interaction between the drug and lipids used. The prepared paroxetine HCl SLNs are characterized for particle size, zeta potential, polydispersity index, entrapment efficiency, drug content and in-vitro drug release. The particle size of paroxetine HCl SLNs ranged from 44.53 to 166.9 nm. The PDI of all formulations were good within the range of 0.270 to 0.485. The zeta potential of drug loaded SLN with lipids (TS and GMS) showed zeta potential ranged from -10.1 to -25.9 mV. Entrapment efficiency of all formulations was within the range of 78.93 to 95.09 %. The cumulative percentage release of optimized formulation (F2) showed good release after 24 hr (90.41 %). The percentage release kinetic studies showed that the release was first order diffusion controlled and the n value (0.42) obtained from the Korsmeyer-Peppas model indicated the release mechanism was Quasi-Fickian type....
Nanoemulsions are the pharmaceutical formulations composed of various particles within a specific size range in nanometers. They have ability to encapsulate the poorly water soluble drug due to their hydrophobic nature. As we know, cancer is the very serious malignancy disorder and until now there is no any specific cure for it. So in order to burst the tumor in cancer and to release the patient from cancer like diseases nanoemulsions can effectively utilized. The main objective of this review is to focus on the various nanoemulsions which can be used in various types of cancer to treat them, also the preparation methods for nanoemulsions for formulation of specific nanoemulsions. Nanoemulsions can effectively used in various types of cancers due to their high lipophilicity, their small droplet size and ability to entrap poorly water soluble drug like paclitaxel (Vit. Enanoemulsion) is a nanoemulsions used in variety of cancers like ovarian cancer, prostate cancer, sometimes in lung cancer. Some other examples are, Curcumin nanoemulsions mostly used in prostrate cancer then CapryolTM-90, Tween 80 (carotenoid nanoemulsions) mostly used in the colon cancer. All of the above examples and their mechanisms showed that nanoemulsions can be easily taken up by tumor cells in malignancy due to their very small droplet size and causes the reduction in the formation of tumor growth also it eliminates the toxicity to healthy cells by cancerous cells and at last they have ability to decrease the migration of cancerous cell toward another/different organs....
The present study was aimed at preparing salicylic acid microemulsion system formulated with garlic oil for topical drug carrier system for better therapeutic effect. Pseudoternary phase diagrams were used to obtain the concentration ranges of the oil (garlic oil), surfactant (tween 20 and tween 80) and co-surfactant (propylene glycol) for microemulsion formation. Four different formulations were formulated with various amount of oil (24 -35%), water (4 -10%) and mixture of surfactant and co-surfactant (60-66%). The microemulsion formulation characterized for its % transmittance, viscosity, pH, drug content, surface morphology, zeta potential, in-vitro drug release and stability evaluation. The optimized microemulsion formulation M2 showed more transmittance, drug content, pH of 6.12, less viscous and 91.91% cumulative drug release. These results indicate that the microemulsion system studied is a promising tool for the topical delivery of salicylic acid....
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